Resumen de Daño y reparación del sistema nervioso
- español
Se presenta un análisis referente al proceso de regeneración de células en el sistema nervioso periférico (SNP), tanto en vertebrados inferiores como en mamíferos adultos; se resaltan los factores de crecimiento de los axones.
- English
At the early part of the last century, the pioneering work of Ramon y Cajal demonstrated that the axons of central nervous system (CNS) neurons are intrinsically able to regenerate. Seventy years later, Aguayo replicated this work confirming that CNS neurons regenerate if they are provided with the right environment, as it is with neurons in the peripheral nervous system (PNS). Since then, intensive work has focused on determining the cellular and molecular mechanisms responsible for supporting regeneration both in the CNS and PNS; as well as determining which components of the central nervous system environment may be hostile to axon regeneration. This review provides an overview of the experimental advances and concepts that have been achieved during recent years in the repair of the CNS after injury. Notwithstanding these recent advances in the field, clear and conclusive evidence for functional regeneration in the adult CNS remains to be shown.
