Is abnormal liver function correlated with food sensitisation in adults?: US NHANES, 2005–2006

I. Shiue

Ayuda

Is abnormal liver function correlated with food sensitisation in adults?: US NHANES, 2005–2006

I. Shiue ^[1]
1. [1] Heriot-Watt University
  
  Heriot-Watt University
  
  Reino Unido
Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 43, Nº. 4 (July–August), 2015, págs. 361-368
Idioma: inglés
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Resumen
- Background Associations between liver function and serum IgE levels have recently been observed in children. However, the relationship in adults is unclear. Therefore, it was aimed to study associations of liver function and serum total and food-specific IgE concentrations in a national and population-based study.
  
  Method Data were retrieved from the United States National Health and Nutrition Examination Surveys, 2005–2006 including demographics, liver status tests, biomarkers, lifestyle factors, and serum total and food-specific IgE concentrations. Participants aged 20 and above were included. Analyses included t-test, chi-square test, and survey-weighted regression modelling.
  
  Results After adjusting for age, sex, ethnicity, vitamin D, waist circumference, family poverty income ratio, total cholesterol, ever asthma, total protein, and survey weighting, abnormal gamma glutamyl transpeptidase was significantly associated with food sensitisation (peanut: OR 2.17, 95%CI 1.60–2.94, P < 0.001; egg: OR 2.55, 95%CI 1.32–4.90, P = 0.008; milk: OR 2.59, 95%CI 1.56–4.31, P = 0.001; shrimp: OR 1.81, 95%CI 1.29–2.55, P = 0.002). Moreover, both abnormal albumin and alanine transaminase were associated with egg sensitisation (OR 1.96, 95%CI 1.12–3.43, P = 0.022 and OR 2.06, 95%CI 1.04–4.09, P = 0.040, respectively).
  
  Conclusion Abnormal liver status tests were correlated with serum food-specific IgE concentrations in adults. Future research with longitudinal design or in clinical settings may be warranted confirming or refuting the observations made in the present epidemiological study.