Vitamin D levels and cognition in elderly adults in China
- Autores: Choy Lye Chei, Prassanna Raman, Zhao-Xue Yin-, Xiao-Ming Shi-, Yi Zeng, David B. Matchar
- Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 62, Nº. 11, 2014, págs. 2125-2129
- Idioma: inglés
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Resumen
Objectives: To evaluate the association between vitamin D level and cognitive impairment in individuals aged 60 and older.
Design: Cross-sectional cohort study.
Setting: Chinese Longitudinal Healthy Longevity Survey, a community-based cohort study in areas in China where the density of centenarians is exceptionally high.
Participants: Individuals with mean age of 84.9 ± 12.7 (N = 2,004).
Measurements: Participants’ cognitive state was evaluated using the Mini-Mental State Examination (MMSE). Vitamin D was measured in plasma using an enzyme-linked immunoassay.
Results: The cross-sectional association between quartiles of plasma vitamin D level and cognitive impairment (MMSE score <18) was modeled using logistic regressions. Plasma vitamin D levels were lower in individuals with cognitive impairment (31.9 ± 15.3 nmol/L) than in those without (45.6 ± 19.6 nmol/L). There was a reverse association between plasma vitamin D and cognitive impairment. After adjusting for age, sex, chronic conditions, smoking and drinking habits, outdoor activities, depression, and activity of daily living limitations, the association remained significant. The multivariable-adjusted odds ratio for lowest versus highest vitamin D levels was 2.15 (95% confidence interval (CI) = 1.05–4.41) for cognitive impairment, and the multivariable odds ratio associated with a 1-standard deviation decrement in plasma vitamin D was 1.32 (95% CI = 1.00–1.74) for cognitive impairment.
Conclusion: Low plasma vitamin D levels were associated with greater odds of cognitive impairment. Further prospective studies in Asian populations are needed to examine the causal direction of this association.
