Resumen de Trichosporon inkin as an Emergent Pathogen in Patients With Severe Pemphigus

João Nobrega De Almeida Júnior, Renata Buccheri De Oliveira, Amaro Duarte, Adriana Lopes Motta, Flávia Rossi, Dulce Sachiko Yamamoto De Figueiredo, Gilda Maria Barbaro Del Negro, Valeria Aoki, Celina Wakisaka Maruta, Claudia Giuli Santi, Gil Benard

• Importance To our knowledge, these are the first reports of bloodstream infections by Trichosporon inkin in patients with pemphigus.

  Observations Trichosporon inkin, a novel organism causing bloodstream infection, was detected in 2 patients with pemphigus. An elderly man with pemphigus foliaceus died despite treatment with liposomal amphotericin B, 3 mg/kg/d, and a young girl with pemphigus vulgaris responded to treatment with voriconazole, 8 mg/kg/d, for 24 days. One of the T inkin isolates had a minimal inhibitory concentration of 2 mg/L against amphotericin B, suggesting resistance to the drug.

  Conclusions and Relevance Delayed suspicion of invasive infection by T inkin may result in a poor outcome in patients with severe forms of pemphigus. This opportunistic infection is highly refractory to conventional potent antifungal treatment.