Determination of the Solution Conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP):: An Advanced Chemistry and Biochemistry Project Using NMR and Molecular-Modeling Studies

• Moses Lee ^[1]
  1. [1] Furman University

     Furman University

     Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 73, Nº 2 (February), 1996, págs. 184-187
• Idioma: inglés
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• Resumen

  • The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees.