Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion
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X. Song [1] ; L. Hua [1] ; Y. Xu [1] ; Z. Fang [1] ; Y. Wang [1] ; J. Gao [1] ; Q. Shi [1] ; X. Zhou [1] ; R. Yu [1]
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[1] Xuzhou Medical College
Xuzhou Medical College
China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 17, Nº. 6, 2015, págs. 477-485
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Purpose The present study aimed at investigating the role and potential mechanism of geranylgeranyltransferase I (GGTase-I) on glioma cell migration and invasion.
Methods Wound-healing assay and transwell assay were performed to study whether GGTase-I and Ras-like GTPase B (RalB) have effect on glioma cell migration and invasion.
Results We found that knockdown of GGTase-I or RalB both significantly decreased the migratory and invasive abilities of glioma cells. GGTase-I down-regulation suppressed RalB membrane association. Moreover, down-regulation of RalB partially abolished the effect of GGTβ over-expression-induced glioma cell migration and invasion increase.
Conclusions These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.
