Resumen de Evolution of physico-mathematical models in radiobiology and their application in ionizing radiation therapies

Oscar Gabriel Garzon, Maria Cristina Plazas, Edison de Jesus Salazar

• español

  La radiobiología es la ciencia encargada del estudio de la interacción de la radiación con los tejidos biológicos y de los efectos producidos sobre ellos. En este trabajo se presentan algunos modelos Físi-co-Matemáticos en Radiobiología, que se han desarrollado para la comparación y cuantificación de la efectividad de diferentes regímenes de radiación. Diferentes investigadores han logrado desarrollar modelos empíricos, basados en consideraciones experimentales y modelos a partir de bases radioló-gicas. En una aplicación a las terapias con radiaciones ionizantes, los estudios logran relacionar va-rios parámetros importantes tales como dosis por fracción, dosis total y el tiempo del tratamiento para obtener un mejor índice terapéutico. En este trabajo, se pretende describir y discutir algunos as-pectos radiobiológicos, de los resultados obtenidos en todo su desarrollo, tales como: Curvas de Iso-efecto, Dosis Nominal Estándar (NDS), Factor Dosis-Tiempo de Fraccionamiento (TDF), Curvas de supervivencia Celular y finalmente se analiza el Modelo Lineal Cuadrático.

• English

  Radiobiology is the science of studying the interaction between radiation and biological tissues and the effects of the first on the latter. In this paper, we present various Physico-Mathematical models used in Radiobiology, which have been developed in order to compare and quantify the effectiveness of different radiation regimens. Different researchers have developed empirical models based on experimental considerations and on a radiological foundation. In one application of ionizing radiation therapies, the studies were able to relate several important parameters, such as dose per fraction, total dose, and the treatment time needed to obtain a better therapeutic index. In this paper, we aim to describe and discuss a number of radiobiological aspects of the results obtained throughout past research, such as Isoeffect Curves, Nominal Standard Dose (NDS), time-dose fractionation factors (TDF), and cell survival curves. Finally, we analyze the Linear-Quadratic ModelRadiobiology is the science of studying the interaction between radiation and biological tissues and the effects of the first on the latter. In this paper, we present various Physico-Mathematical models used in Radiobiology, which have been developed in order to compare and quantify the effectiveness of different radiation regimens. Different researchers have developed empirical models based on experimental considerations and on a radiological foundation. In one application of ionizing radiation therapies, the studies were able to relate several important parameters, such as dose per fraction, total dose, and the treatment time needed to obtain a better therapeutic index. In this paper, we aim to describe and discuss a number of radiobiological aspects of the results obtained throughout past research, such as Isoeffect Curves, Nominal Standard Dose (NDS), time-dose fractionation factors (TDF), and cell survival curves. Finally, we analyze the Linear-Quadratic Model