Student-Driven Design of Peptide Mimetics: Microwave-Assisted Synthesis of Peptoid Oligomers

• Nicola L. B. Pohl ^[1] ; Kent Kirshenbaum ^[2] ; Barney Yoo ^[2] ; Nathan Schulz ^[1] ; Corbin J. Zea ^[1] ; Jennifer M. Streff ^[1] ; Kimberly L. Schwarz ^[1]
  1. [1] New York University

     New York University

     Estados Unidos

     
  2. [2] Iowa State University

     Iowa State University

     Township of Franklin, Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 88, Nº 7, 2011, págs. 999-1001
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • An experiment for the undergraduate organic laboratory is described in which peptide mimetic oligomers called “peptoids” are built stepwise on a solid-phase resin. Students employ two modern strategies to facilitate rapid multistep syntheses: solid-phase techniques to obviate the need for intermediate purifications and microwave irradiation to enhance reaction rates. The modular reaction protocol is compatible with a vast array of reagents, allowing students to design unique oligomer sequences and to get a sense of modern drug-discovery processes. Students compare reactions performed both with and without microwave irradiation for a collaborative learning experience.