Using Models to Understand and Design Sweeteners

• Autores: D. Eric Walters
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 72, Nº 8 (August), 1995, págs. 680-683
• Idioma: inglés
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• Resumen

  • While most sweeteners have been discovered accidentally, many models have been devised to aid in understanding structure-taste relationships. Because of the diversity of structures which may exhibit sweet taste, it is difficult to devise a comprehensive model. In fact, it may not be appropriate to fit all sweeteners into a single model since multiple receptors may be involved. This paper describes the evolution of sweetness receptor models, culminating in computer-derived models which have successfully been used in the design of new sweeteners and in predicting how sweet new analogs will be.