Isothermal Titration Calorimetry in the Student Laboratory

• Lars Wadsö ^[1] ; Yujing Li ^[1] ; Xi Li ^[2]
  1. [1] Lund University

     Lund University

     Suecia

     
  2. [2] Wuhan University of Technology

     Wuhan University of Technology

     China

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 88, Nº 1, 2011, págs. 101-105
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Isothermal titration calorimetry (ITC) is the measurement of the heat produced by the stepwise addition of one substance to another. It is a common experimental technique, for example, in pharmaceutical science, to measure equilibrium constants and reaction enthalpies. We describe a stirring device and an injection pump that can be used with a previously described isothermal calorimeter to perform ITC measurements. Two experiments are also described: an acid−base titration and the binding of Ba2+ to the macrocyclic compound 18-crown-6. These experiments visualize the difference between strong and weak interactions (large and small equilibrium constants) and introduce how reaction enthalpies and equilibrium constants can be calculated from titration calorimetric experiments.