Efficacy of Ibuprofen-Hydrocodone for the Treatment of Postoperative Pain After Periodontal Surgery

• Autores: James W. Betancourt, Leo I. Kupp, Samuel J. Jasper, Owais A. Farooqi
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 75, Nº. 6, 2004, págs. 872-876
• Idioma: inglés
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• Resumen

  • Background: Previous studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) have significant benefits in the control of postoperative pain after periodontal or oral surgical procedures. The combination of a peripherally acting NSAID with a centrally acting opioid drug is found to be more effective. The purpose of this study was to compare an alternative combination of ibuprofen 400 mg with 5 mg of hydroxycodone to ibuprofen 400 mg used alone in the management of pain following periodontal surgery.

    Methods: This study used a double-masked cross-over design with the patients acting as their own controls. Twelve patients underwent two periodontal surgeries in different quadrants of the same dental arch at least 2 weeks apart. A standardized amount of local anesthetic and similar extent and duration of surgery for each side was required. The patients received four doses of medication at predetermined intervals and filled out a visual analog pain scale every 2 hours for the first 12 hours after surgery.

    Results: The overall pain reported by the patients on visual analog scale was 1.55 (SE ± 0.16), out of a possible 10. More pain was reported with ibuprofen alone, 1.81 (SE ± 0.12), compared to the ibuprofen with hydrocodone combination, 1.30 (SE ± 0.16). The difference was statistically significant (P <0.05).

    Conclusion: The findings suggest that a combination analgesic preparation of ibuprofen (400 mg) with hydrocodone (5 mg) results in better pain control compared to ibuprofen used alone. J Periodontol 2004;75:872-876.