Estrogen and/or Calcium Plus Vitamin D Increase Mandibular Bone Mass

• Autores: Charles Hildebolt, Thomas K. Pilgram, Mary Dotson, Reina Armamento-Villareal, Jay Hauser, Sheldon Cohen, Roberto Civitelli
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 75, Nº. 6, 2004, págs. 811-816
• Idioma: inglés
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• Resumen

  • Background: We have previously reported that estrogen/ hormone replacement therapy (E/HRT) has beneficial effects on oral bone density over 3 years and that calcium and vitamin D supplementation has a lesser effect. Here we report on mandibular bone mass for 49 women (of the original cohort of 135) who continued in an additional 2-year, open-label extension.

    Methods: Postmenopausal women were randomly assigned to receive calcium and vitamin D plus E/HRT, or calcium and vitamin D only. Regression analysis of mandibular bone mass over time was performed for each woman.

    Results: Twenty-two of 26 women who took calcium and vitamin D plus E/HRT for 5 years had small mandibular bone mass increases (0.35 ± 0.38%, P <0.001). Seventeen of 19 women who took only calcium and vitamin D for 3 years had increases in mandibular bone mass (0.74 ± 0.89%, P <0.002). The largest gains in mandibular bone mass occurred during the first 3 years of the study.

    Conclusions: The data of this study indicate that E/HRT and/or calcium and vitamin D may result in increases of mandibular bone mass in postmenopausal women. Because of the longterm risks associated with E/HRT, caution should be exercised in prescribing E/HRT for prevention of chronic menopausal conditions. J Periodontol 2004;75:811-816.