Resumen de Locally Delivered Doxycycline as an Adjunctive Therapy to Scaling and Root Planing in the Treatment of Smokers: A Clinical Study
Luciana Machion, Denise Carleto Andia, Bruno Braga Benatti, Marcelo Diniz Carvalho, Getúlio da R. Nogueira-Filho, Marcio Zaffalon Casati, Francisco Humberto Nociti, Enilson Antonio Sallum
Background: The aim of this clinical study was to evaluate the association of locally delivered doxycycline (10%) with scaling and root planing in the periodontal treatment of smokers.
Methods: Forty-three patients with chronic periodontitis and a minimum of four pockets (≥5 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP-D). Plaque, bleeding on probing, gingival recession, relative attachment level RAL), and probing depth (PD) were recorded at baseline, 45 days, and 3 and 6 months. Differences between baseline and each period were considered for analysis.
Results: At 6 months, no difference was found between groups regarding plaque, bleeding reduction, gingival recession or PD (P >0.05). However, RAL gain was greater for SRP-D (1.63 ± 0.93 mm) than for SRP (1.04 ± 0.71 mm) (P = 0.025). In addition, deep pockets (≥7 mm) showed a significant reduction (3.78 ± 1.41 versus 2.60 ± 1.28 mm, P = 0.039) and RAL gain (2.54 ± 1.27 mm versus 1.29 ± 0.95 mm, P = 0.01) when doxycycline was applied. The proportion of sites showing RAL gain of 1 to 2 mm was 36.8% versus 21.7% for SRP-D and SRP, respectively (P = 0.01).
Conclusion: The use of locally delivered doxycycline may constitute an important adjunct for the treatment of severe periodontal disease in smokers. J Periodontol 2004;75:464-469.
