P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma
- Autores: Elba Rosa Leyva Huerta, Constantino Ledesma Montes, Rebeca Estela Rojo Botello, María Elisa Vega Memije
- Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 17, Nº. 5 (septiembre), 2012
- Idioma: inglés
- Enlaces
- Dialnet Métricas: 2 Citas
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Resumen
Objective :
The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).
Study D esign :
We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies.
Results : We found p53 immunoexpression in 71.4 % OLP cases and 68.7 % OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy.
Conclusions :
Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease.
