Peripheral Neuropathy Defined by Monofilament Insensitivity and Diabetes Status: NHANES 1999-2004

• Autores: Jodie G. Katon, Gayle E. Reiber, Karin M. Nelson
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 36, Nº. 6, 2013, págs. 1604-1606
• Idioma: inglés
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• Resumen

  • OBJECTIVE-To determine whether diabetes status, including prediabetes, is associated with increased risk of peripheral neuropathy as defined by monofilament insensitivity.

    RESEARCH DESIGN AND METHODS-This study used data from the 1999-2004 National Health and Nutrition Examination Survey (n = 7,818). Peripheral neuropathy was defined as one or more insensate sites detected by a Semmes-Weinstein 10-g monofilament. Generalized linear models were used to directly estimate relative risks (RRs) for the association of diabetes status and peripheral neuropathy.

    RESULTS-After adjustment compared with no diabetes, prediabetes [RR 1.11 (95% CI 0.92-1.34)] and undiagnosed diabetes [1.08 (0.73-1.61)] were associated with modest increases in risk of peripheral neuropathy, and diabetes was associated with a 74% higher risk of peripheral neuropathy [1.74 (1.50-2.01)].

    CONCLUSIONS-Diabetes is associated with increased risk of peripheral neuropathy defined by monofilament insensitivity, but prediabetes and undiagnosed diabetes may be associated with only a modest increase in risk.