Resumen de Age-Related and Surgically Induced Estrogen Deficiencies May Differently Affect Bone Around Titanium Implants in Rats
Poliana Mendes Duarte, Patrícia Furtado Gonçalves, Marcio Zaffalon Casati, Enilson Antonio Sallum, Dr. Francisco Humberto Nociti
Background: Valuable information has been obtained using the ovariectomy model; however, clinical studies have indicated that such a model may not be appropriate to parallel with the postmenopausal condition and titanium implants. Thus, this study aimed to comparatively evaluate, by histometric analysis, the influence of age-related (ARED) and surgically induced (OVX) estrogen deficiencies on bone around titanium implants inserted in rats.
Methods: Single screw-shaped titanium implants were placed in rat tibiae and animals were then assigned to one of the following groups: SHAM (N = 15): bilateral sham ovariectomies in 90-day-old rats, 21 days before implant placement; OVX (N = 15): bilateral ovariectomies in 90-day-old rats, 21 days before implant placement; and ARED (N = 15): implant placement in reproductive aged rats (22 months old). After 60 days, the animals were sacrificed and undecalcified sections obtained. Boneto- implant contact (BIC) and bone area (BA) within the limits of implant threads and bone density (BD) in a 500 µm-wide zone lateral to the implant were obtained and arranged for cortical (zone A) and cancellous (zone B) bone regions.
Results: For zone A, intergroup analysis showed no signifi- cant differences regarding BIC and BA (P >0.05). In contrast, ARED negatively influenced BD around the implants (P <0.05). In zone B, OVX negatively affected BIC and BA (P <0.05), and both ARED and OVX groups demonstrated lower BD than the SHAM group (P <0.05).
Conclusion: Within the limits of this study, it can be concluded that ARED mainly affects preexisting bone while OVX more significantly affects both newly formed and preexisting bone. J Periodontol 2005;76:1496-1501.
