Resumen de The Effectiveness of 1% Pimecrolimus Cream in the Treatment of Oral Erosive Lichen Planus

Julie C. Swift, Terry D. Rees, Jacqueline M. Plemons, William W. Hallmon, John C. Wright

• Background: The purpose of this study was to evaluate the efficacy, relative safety, and tolerability of 1% pimecrolimus cream in the treatment of oral erosive lichen planus (OELP).

  Methods: Twenty patients with OELP were randomized into equal groups; group 1 applied 1% pimecrolimus cream twice daily to their oral lesions for 4 weeks, whereas group 2 applied a placebo cream. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation. Discomfort scores were also assessed with a visual analogue scale (VAS). Blood samples were taken at baseline and at study completion; a complete blood count with differential and comprehensive metabolic panel was ordered. The Wilcoxon signed rank test was used.

  Results: The experimental group showed a decrease in ulceration (α = 0.068) and erythema (α = 0.005) at the mid-point with continued reduction of erythema at the final (α = 0.075) time measurement. The control group demonstrated an increase in reticulation at the mid-point (α = 0.017) and final (α = 0.007) time measurement. The VAS scores for the experimental group decreased during the study (α = 0.022). Blood levels were within the normal range.

  Conclusions: The OELP lesion size in the 1% pimecrolimus group decreased and the pimecrolimus cream was found to significantly reduce the patient's pain scores. Further study of 1% pimecrolimus as therapy for OELP is warranted since it was shown to be effective, relatively safe, and well tolerated by patients within the limits of this short-term study. J Periodontol 2005;76:627-635.