Cidofovir Gel as Treatment of Follicular Spicules in Multiple Myeloma

• Autores: Terry Jones, Sander van Boheemen, Barbara Muhlemann, Mariet C. Feltkamp, Ron A. M Fouchier, Enes Hajdarbegovic
• Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 151, Nº. 1, 2015, págs. 82-84
• Idioma: inglés
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• Resumen

  • Importance The cause of follicular spicules in multiple myeloma (MM) is not known.

    Observations We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa–associated polyomavirus could be isolated from the skin lesions; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomavirus.

    Conclusions and Relevance Follicular spicules in MM are probably not caused by the trichodysplasia spinulosa–associated virus. Merkel cell polyomavirus could contribute to the origin of this dermatosis.