Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009–2014)
- Autores: Damiano Stefanello, Paolo Buracco, Silvia Sabattini, Riccardo Finotello, Chiara Giudice, Valeria Grieco, Selina Iussich, Massimiliano Tursi, Timothy Scase, Stefano Di Palma, Giuliano Bettini , Roberta Ferrari, Marina Martano, Francesca Gattino, Mary Marrington, Mónica Mazzola, Maria Elisabetta Vasconi, Maurizio Annoni, Laura Marconato
- Localización: JAVMA: Journal of the American Veterinary Medical Association, ISSN-e 0003-1488, Vol. 246, Nº. 7, 2015, págs. 765-769
- Idioma: inglés
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Resumen
Presented in part at the Annual European Society of Veterinary Oncology Congress, Vienna, May 2014.
Address correspondence to Dr. Marconato (marconato@centroncologicovet.it).
Objective—To compare the Kiupel (2 categories) and Patnaik (3 categories) histologic grading systems for predicting the presence of metastasis at the time of initial examination in dogs with cutaneous mast cell tumors (MCTs).
Design—Retrospective case series.
Animals—386 client-owned dogs with cutaneous MCTs.
Procedures—Medical records of dogs with newly diagnosed, histologically confirmed cutaneous MCTs that had undergone complete clinical staging were reviewed for clinical and histopathologic data.
Results—All Patnaik grade 1 MCTs (n = 52) were classified as Kiupel low-grade MCTs, and all Patnaik grade 3 MCTs (43) were classified as Kiupel high-grade MCTs. Of the 291 Patnaik grade 2 MCTs, 243 (83.5%) were classified as Kiupel low-grade tumors, and 48 (16.5%) were classified as Kiupel high-grade MCTs. Dogs with Patnaik grade 3 MCTs were significantly more likely to have metastases at the time of initial examination than were dogs with grade 1 or 2 MCTs (OR, 5.46), and dogs with Kiupel high-grade MCTs were significantly more likely to have metastases than were dogs with Kiupel low-grade MCTs (OR, 2.54). However, 3 of 52 (5.8%) dogs with Patnaik grade 1 tumors, 48 of 291 (16.5%) dogs with Patnaik grade 2 tumors, and 44 of 295 (14.9%) dogs with Kiupel low-grade tumors had metastatic disease.
Conclusions and Clinical Relevance—Findings indicated that in dogs with cutaneous MCTs, prognostication should not rely on histologic grade alone, regardless of grading system used, but should take into account results of clinical staging.
