Selective Cyclooxygenase-2 Inhibitor May Impair Bone Healing Around Titanium Implants in Rats
- Autores: Fernada Vieira Ribeiro, João Batista César-Neto, Sergio de Toledo Toledo, Marcio Zaffalon Casati
- Localización: Journal of periodontology, ISSN 0022-3492, Vol. 77, Nº. 10, 2006, págs. 1731-1735
- Idioma: inglés
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Resumen
Background: The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor, meloxicam, on bone healing around titanium implants in rats.
Methods: Thirty-one adult male Wistar rats were included in this study, and one screw-shaped titanium implant was inserted in the tibiae of each rat. The animals were randomly assigned to one of the following groups for daily subcutaneous injections: control (N = 14): saline solution; and test (N = 17): 3 mg/kg of meloxicam, each administered daily for 60 days. After the treatment, animals were sacrificed, and undecalcified sections were obtained. Bone-to-implant contact (BIC) and bone area (BA) within the limits of implant threads and bone density (BD) in a 500 μm-wide zone lateral to the implants were obtained and arranged for cortical (zone A) and cancellous (zone B) bone regions.
Results: Intergroup comparisons demonstrated that meloxicam significantly reduced bone healing around implants. For zone A, significant differences were observed regarding BIC (47.01 ± 10.48 A; 35.93 ± 12.25 B), BA (86.42 ± 3.66 A; 61.58 ± 12.09 B), and BD (96.86 ± 0.96 A; 91.06 ± 3.05 B) for control and test groups, respectively (P <0.05). For zone B, data analysis also showed significant differences among groups for BIC (30.76 ± 13.80 A; 16.86 ± 11.48 B), BA (34.83 ± 8.18 A; 25.66 ± 9.16 B), and BD (15.76 ± 7.05 A; 7.73 ± 4.61 B) for control and test groups, respectively (P <0.05).
Conclusion: Meloxicam may negatively influence bone healing in the cortical and cancellous bone around titanium implants inserted in rats after continuous administration.
