Five-Year Follow-Up of Regenerative Periodontal Therapy With Enamel Matrix Derivative at Sites With Angular Bone Defects

• Autores: Gunnar Heden, Jan L. Wennström
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 77, Nº. 2, 2006, págs. 295-301
• Idioma: inglés
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• Resumen

  • Five-Year Follow-Up of Regenerative Periodontal Therapy With Enamel Matrix Derivative at Sites With Angular Bone Defects Gunnar Heden*† and Jan L. Wennström† *Department of Periodontology, Public Dental Service, Karlstad, Värmland, Sweden.

    †Department of Periodontology, Faculty of Odontology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

    Correspondence: Dr. Gunnar Heden, Department of Periodontology, Public Dental Service, Älvgatan 47, SE 652 30, Karlstad, Sweden. Fax: 46-54-185964; e-mail: Gunnar.Heden@liv.se.

    Background: This prospective case series report aimed at analyzing the long-term (5 years) stability of clinical attachment level (CAL) gains following regenerative therapy with the use of enamel matrix proteins in intrabony defects.

    Methods: A total of 114 consecutively treated periodontal patients (mean age: 55.8 years) were initially included. Each subject exhibited at least one deep proximal intrabony defect with the inclusion criteria of 1) probing depth (PD) ≥5 mm, 2) clinical attachment loss ≥6 mm, and 3) radiographic evidence of a ≥3-mm intrabony component. A total of 146 defects met the criteria for inclusion. At least 6 months after the completion of an initial phase of mechanical infection control, a baseline examination was performed to characterize the experimental site. Reconstructive therapy with the use of enamel matrix proteins was subsequently performed. Experimental sites were reexamined 1 and 5 years after reconstructive surgery. Primary efficacy variables were considered to be changes in PD, CAL, soft tissue recession (REC), and radiographic defect depth (RDD). Stepwise regression analysis was employed for evaluation of predicting factors of CAL change between the 1- and 5-year reexaminations.

    Results: A total of 82 patients (102 defects) were included in the analysis. One year following the regenerative surgery, a mean CAL gain of 4.3 mm (P <0.001), a mean PD reduction of 4.9 mm (P <0.001), and a mean increase in REC of 0.6 mm (P <0.001) were recorded. At the 5-year follow-up, a further mean PD reduction of 0.3 mm (P >0.05), CAL gain of 1.1 mm (P <0.01), and reduction in recession of 0.8 mm (P <0.01) had taken place. Radiographs revealed that the bone defect had been reduced in depth with an average of 2.9 mm at 1 year (P <0.001). No statistically significant alteration in defect depth was observed between 1 and 5 years of follow-up. The stepwise regression analysis identified the degree of REC and residual PD at 1 year as significant predictors of CAL change between 1 and 5 years.

    Conclusion: Results demonstrated long-term (5 years) stability of CAL gains following regenerative therapy with the use of enamel matrix proteins in intrabony defects.

    KEYWORDS: Bone, defects, enamel matrix proteins, regeneration Cited by Girish Bhutda and Vikas Deo. (2013) Five years clinical results following treatment of human intra-bony defects with an enamel matrix derivative: A randomized controlled trial. Acta Odontologica Scandinavica 71, 764-770.

    Online publication date: 1-May-2013.

    CrossRef Brook A. Niemiec and Robert Furman. 2013. Osseous Surgery and Guided Tissue Regeneration. Veterinary Periodontology, 254-288.

    CrossRef Eugenio Broccaioli, Stefania Niada, Giulio Rasperini, Lorena Maria Ferreira, Elena Arrigoni, Vijay Yenagi and Anna Teresa Brini. (2013) Mesenchymal Stem Cells from Bichat's Fat Pad: In Vitro Comparison with Adipose-Derived Stem Cells from Subcutaneous Tissue. BioResearch Open Access 2, 107-117.

    Online publication date: 1-Apr-2013.

    CrossRef Takuya Takanashi, Koushu Fujinami, Mai Matsuzaki, Hideshi Sekine and Atsushi Saito. (2012) Treatment of Generalized Aggressive Periodontitis With Enamel Matrix Derivative and Implant Prosthesis: A Case Report. Clinical Advances in Periodontics 2:3, 187-194.

    Online publication date: 1-Aug-2012.

    Abstract | Full Text | PDF (2344 KB) | PDF Plus (876 KB) Mamdouh M. Karima and Thomas E. Van Dyke. (2012) Enamel Matrix Derivative Promotes Superoxide Production and Chemotaxis but Reduces Matrix Metalloproteinase-8 Expression by Polymorphonuclear Leukocytes. Journal of Periodontology 83:6, 780-786.

    Online publication date: 1-Jun-2012.

    Abstract | Full Text | PDF (548 KB) | PDF Plus (536 KB) Burcu Özdemir and Emel Ökte. (2012) Treatment of intrabony defects with beta-tricalciumphosphate alone and in combination with platelet-rich plasma. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100B:10.1002/jbm.b.v100b.4, 976-983.

    Online publication date: 1-May-2012.

    CrossRef Javier Catón, Nagihan Bostanci, Eumorphia Remboutsika, Cosimo De Bari and Thimios A. Mitsiadis. (2011) Future dentistry: cell therapy meets tooth and periodontal repair and regeneration. Journal of Cellular and Molecular Medicine 15:10.1111/jcmm.2011.15.issue-5, 1054-1065.

    Online publication date: 1-May-2011.

    CrossRef Vincenzo Iorio Siciliano, Gianmaria Andreuccetti, Alessandro Iorio Siciliano, Andrea Blasi, Anton Sculean and Giovanni E. Salvi. (2010) Clinical Outcomes After Treatment of Non-Contained Intrabony Defects With Enamel Matrix Derivative or Guided Tissue Regeneration: A 12-Month Randomized Controlled Clinical Trial. Journal of Periodontology 82:1, 62-71.

    Online publication date: 1-Jan-2011.

    Abstract | Full Text | PDF (1759 KB) | PDF Plus (737 KB) Renato Corrêa Viana Casarin, Érica Del Peloso Ribeiro, Francisco Humberto Nociti, Antônio Wilson Sallum, Gláucia Maria Bovi Ambrosano, Enilson Antônio Sallum and Márcio Zaffalon Casati. (2010) Enamel matrix derivative proteins for the treatment of proximal class II furcation involvements: a prospective 24-month randomized clinical trial. Journal of Clinical Periodontology 37:10.1111/cpe.2010.37.issue-12, 1100-1109.

    Online publication date: 1-Dec-2010.

    CrossRef Fa-Ming Chen, Jing Zhang, Min Zhang, Ying An, Fang Chen and Zhi-Fen Wu. (2010) A review on endogenous regenerative technology in periodontal regenerative medicine. Biomaterials 31, 7892-7927.

    Online publication date: 1-Nov-2010.

    CrossRef Per Nygaard-Østby, Vibeke Bakke, Oddny Nesdal, Cristiano Susin and Ulf M. E. Wikesjö. (2010) Periodontal healing following reconstructive surgery: effect of guided tissue regeneration using a bioresorbable barrier device when combined with autogenous bone grafting. A randomized-controlled trial 10-year follow-up. Journal of Clinical Periodontology 37:10.1111/cpe.2010.37.issue-4, 366-373.

    Online publication date: 1-Apr-2010.

    CrossRef SP Lyngstadaas, JC Wohlfahrt, SJ Brookes, ML Paine, ML Snead and JE Reseland. (2009) Enamel matrix proteins; old molecules for new applications. Orthodontics & Craniofacial Research 12:10.1111/ocr.2009.12.issue-3, 243-253.

    Online publication date: 1-Aug-2009.

    CrossRef Richard T. Kao, Shinya Murakami and O. Ross Beirne. (2009) The use of biologic mediators and tissue engineering in dentistry. Periodontology 2000 50:10.1111/prd.2009.50.issue-1, 127-153.

    Online publication date: 1-Jun-2009.

    CrossRef Alessandro Crea, Leonardo Dassatti, Oliver Hoffmann, Gregory-George Zafiropoulos and Giorgio Deli. (2008) Treatment of Intrabony Defects Using Guided Tissue Regeneration or Enamel Matrix Derivative: A 3-Year Prospective Randomized Clinical Study. Journal of Periodontology 79:12, 2281-2289.

    Online publication date: 1-Dec-2008.

    Abstract | Full Text | PDF (1177 KB) | PDF Plus (615 KB) Neel B. Bhatavadekar and David W. Paquette. (2008) Long-Term Follow-Up and Tomographic Assessment of an Intrabony Defect Treated With Enamel Matrix Derivative. Journal of Periodontology 79:9, 1802-1808.

    Online publication date: 1-Sep-2008.

    Abstract | Full Text | PDF (1216 KB) | PDF Plus (607 KB) Anton Sculean, Alice Kiss, Asta Miliauskaite, Frank Schwarz, Nicole B. Arweiler and Matthias Hannig. (2008) Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. Journal of Clinical Periodontology 35:10.1111/cpe.2008.35.issue-9, 817-824.

    Online publication date: 1-Sep-2008.

    CrossRef Francesca Gaunt, Maria Devine, Mark Pennington, Chris Vernazza, Erika Gwynnett, Nick Steen and Peter Heasman. (2008) The cost-effectiveness of supportive periodontal care for patients with chronic periodontitis. Journal of Clinical Periodontology 35:10.1111/cpe.2008.35.issue-s8, 67-82.

    Online publication date: 1-Sep-2008.

    CrossRef Leonardo Trombelli and Roberto Farina. (2008) Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. Journal of Clinical Periodontology 35:10.1111/cpe.2008.35.issue-s8, 117-135.

    Online publication date: 1-Sep-2008.

    CrossRef Giuseppe Intini, Sebastiano Andreana, Robert J. Buhite and Libuse A. Bobek. (2008) A Comparative Analysis of Bone Formation Induced by Human Demineralized Freeze-Dried Bone and Enamel Matrix Derivative in Rat Calvaria Critical-Size Bone Defects. Journal of Periodontology 79:7, 1217-1224.

    Online publication date: 1-Jul-2008.

    Abstract | Full Text | PDF (2228 KB) | PDF Plus (805 KB) Christer Slotte, Barbro Asklöw and Dan Lundgren. (2007) Surgical guided tissue regeneration treatment of advanced periodontal defects: a 5-year follow-up study. Journal of Clinical Periodontology 34:10.1111/cpe.2007.34.issue-11, 977-984.

    Online publication date: 1-Nov-2007.

    CrossRef Anton Sculean, Malgorzata Pietruska, Nicole B. Arweiler, Thorsten M. Auschill and Carlos Nemcovsky. (2007) Four-year results of a prospective-controlled clinical study evaluating healing of intra-bony defects following treatment with an enamel matrix protein derivative alone or combined with a bioactive glass. Journal of Clinical Periodontology 34:10.1111/cpe.2007.34.issue-6, 507-513.

    Online publication date: 1-Jun-2007.

    CrossRef Brian L. Foster, Tracy E. Popowics, Hanson K. Fong and Martha J. Somerman. 2007. Advances in Defining Regulators of Cementum Development and Periodontal Regeneration. Current Topics in Developmental Biology, 47-126.

    CrossRef Anton Sculean, Frank Schwarz, Asta Miliauskaite, Alice Kiss, Nicole Arweiler, Jürgen Becker and Michel Brecx. (2006) Treatment of Intrabony Defects With an Enamel Matrix Protein Derivative or Bioabsorbable Membrane: An 8-Year Follow-Up Split-Mouth Study. Journal of Periodontology 77:11, 1879-1886.

    Online publication date: 1-Nov-2006.

    Abstract | Full Text | PDF (173 KB) | PDF Plus (230 KB) JAN L. WENNSTRÖM and CRISTIANO TOMASI. (2006) Periodontal infection control: current clinical concepts. Endodontic Topics 13:10.1111/etp.2006.13.issue-1, 3-12.

    Online publication date: 1-Mar-2006.