Resumen de A Morphologic Comparison of Gingival Changes Influenced by Cyclosporin and Tacrolimus in Rats: An Experimental Study
A Morphologic Comparison of Gingival Changes Influenced by Cyclosporin and Tacrolimus in Rats: An Experimental Study Ashwin Prabhu* and D.S. Mehta* *Department of Periodontology and Implantology, Bapuji Dental College and Hospital, Davangere, Karnataka State, India.
Correspondence: Dr. D.S. Mehta, Department of Periodontology and Implantology, Bapuji Dental College and Hospital, Davangere-577004, Karnataka State, India. Fax: 91-8192-220578; e-mail: dsmehta99@rediffmail.com.
Background: The aim of this study was to compare the morphologic changes in the gingiva brought about by the administration of cyclosporin and tacrolimus in rats.
Methods: The study was conducted on 30 six-week-old male Sprague-Dawley rats, divided into three groups of 10 rats each, for a period of 4 weeks. Group I rats received cyclosporin (30 mg/kg body weight), and group II rats received tacrolimus (1.5 mg/kg body weight), by means of a gavage. Group III served as control and received olive oil alone. Impressions of the mandibular incisal region were made weekly, and stone casts were prepared for measuring morphologic changes of the gingiva.
Results: An increase in the measured gingival dimensions was observed in the test groups as early as week 2 after the commencement of drug administration. Intergroup comparison revealed that the increase in the measured dimensions was greater in group I than group II at the end of 4 weeks.
Conclusions: Cyclosporin and tacrolimus were capable of causing gingival enlargement in Sprague-Dawley rats. However, the magnitude of tacrolimus-influenced gingival enlargement seemed to be comparatively less than cyclosporin.
KEYWORDS: Cyclosporin, gingival enlargement, immunosuppressant, tacrolimus Cited by F. Pamuk, B. O. Cetinkaya, B. Ayas, G. C. Keles and A. Gacar. (2014) Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study. Journal of Periodontal Research, n/a-n/a.
Online publication date: 1-Nov-2014.
CrossRef Ferda Pamuk, Burcu Ozkan Cetinkaya, Mustafa Yavuz Gulbahar, Ayhan Gacar, Gonca Cay\x{0131}r Keles, Zuleyha Erisgin and Nurol Arik. (2013) Effects of Tacrolimus and Nifedipine, Alone or in Combination, on Gingival Tissues. Journal of Periodontology 84:11, 1673-1682.
Online publication date: 1-Nov-2013.
Abstract | Full Text | PDF (1606 KB) | PDF Plus (693 KB) P.E. Bottura, J. Milanezi, L.A. Fernandes, H.C. Caldas, M. Abbud-Filho, V.G. Garcia and M.A.S.F. Baptista. (2011) Nonsurgical Periodontal Therapy Combined with Laser and Photodynamic Therapies for Periodontal Disease in Immunosuppressed Rats. Transplantation Proceedings 43, 2009-2016.
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