Resumen de The Effects of Antimicrobial Sprays and Mouthrinses on Supragingival Plaque Regrowth: A Comparative Study
Giovanna Giuliana, Rosario Guiglia, Giuseppe Pizzo, Mario Imburgia, Ignazio Pizzo, Matteo D'Angelo
The Effects of Antimicrobial Sprays and Mouthrinses on Supragingival Plaque Regrowth: A Comparative Study Giuseppe Pizzo,* Rosario Guiglia,* Mario Imburgia,* Ignazio Pizzo,† Matteo D'Angelo,* and Giovanna Giuliana† *Department of Oral Sciences, Section of Periodontology, University of Palermo, Palermo, Italy.
†Department of Oral Sciences, Section of Pediatric Dentistry, University of Palermo.
Correspondence: Dr. Giuseppe Pizzo, Department of Oral Sciences, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy. Fax: 39-091-6552202; e-mail: giuseppepizzo@odonto.unipa.it.
Background: Due to the side effects of chlorhexidine digluconate (CHX) mouthrinsing, a spray has been proposed as an alternative method of CHX delivery to the oral cavity. The aim of this study was to investigate the plaque inhibitory effects of CHX, cetylpyridinium chloride (CPC), and triclosan (TRN) delivered by sprays and mouthrinses.
Methods: The study was an observer-masked, randomized cross-over design balanced for carryover effects, involving 15 healthy volunteers in a 4-day plaque regrowth model. Products being tested (0.2% CHX, 0.12% CHX, 0.05% CPC, and 0.03% TRN) were used both as sprays and mouthrinses. A saline solution served as a negative control. On day 1, subjects received professional prophylaxis, suspended oral hygiene measures, and commenced using their allocated products. On day 5, subjects were scored for disclosed plaque.
Results: CHX sprays (P <0.01) were the most effective sprays in preventing plaque regrowth, without significant differences between the two concentrations tested (P >0.05). TRN spray showed a significant inhibition of plaque regrowth in comparison to the negative control (P <0.05). CPC spray did not differ from saline spray (P >0.05). A similar trend of efficacy was detected for rinses. Although the effect on plaque regrowth observed with CHX rinses was superior to that of CHX sprays (P <0.0003), the latter did not cause side effects (P >0.2).
Conclusions: These findings, together with those from clinical trials, suggest that the CHX-containing sprays may represent an effective alternative to CHX rinses when mechanical oral hygiene has to be avoided in restricted areas. On the contrary, the TRN and CPC sprays showed little or no plaque inhibitory effects.
KEYWORDS: Cetylpyridinium chloride/therapeutic use, chlorhexidine/therapeutic use, dental plaque/prevention and control, mouthrinse/therapeutic use, spray/therapeutic use, triclosan/therapeutic use Cited by Ş. Kurgan, C. Önder, S. M. Altıngöz, N. Bağış, M. Uyanık, M. A. Serdar and A. Kantarcı. (2015) High sensitivity detection of salivary 8-hydroxy deoxyguanosine levels in patients with chronic periodontitis. Journal of Periodontal Research, n/a-n/a.
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