Myeloid Sarcoma Occurring Concurrently With Drug-Induced Gingival Enlargement
- Autores: Angela J. Yoon, Carla Pulse, Lori D. Cohen, Timothy A. Lew, David J. Zegarelli
- Localización: Journal of periodontology, ISSN 0022-3492, Vol. 77, Nº. 1, 2006, págs. 119-122
- Idioma: inglés
- Enlaces
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Resumen
Correspondence: Dr. David J. Zegarelli, Department of Pathology, College of Physicians and Surgeons, Columbia University Medical Center, 630 W. 168th St., PH-1562, New York, NY 10032. Fax: 212/305-5958; e-mail: djz1@columbia.edu.
Background: Myeloid sarcoma is an extramedullary malignancy of myeloblasts. An unusual case of myeloid sarcoma presenting in the gingiva and affected by drug-induced gingival enlargement is presented.
Methods: A 63-year-old male taking amlodipine for his hypertension presented with a 3-week gingival enlargement. Although the obvious clinical impression was that of drug-induced gingival enlargement, an incisional biopsy was performed to corroborate chemical enlargement while ruling out diseases such as lymphoma and leukemia.
Results: Microscopic examination of the thickened gingiva revealed surface stratified squamous epithelium having needle-like rete pegs characteristic of drug-induced gingival enlargement. Beneath the surface epithelium, the fibrous tissue was virtually replaced by a dense infiltrate of malignant cells. Immunohistochemical studies were performed with CD117 and myeloperoxidase identifying the malignant cell population as myeloblasts, leading to a diagnosis of myeloid sarcoma.
Conclusion: Myeloid sarcoma and hematopoietic malignancies must be included in a differential diagnosis of gingival enlargement until the definitive diagnosis is reached by histologic/laboratory examination.
