Resumen de Use of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide (P-15) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans

Patricia R. Cury, Ana L. Eto, Julio C. Joly, Marjorie K. Jeffcoat, Ney Araujo, Vera Cavalcanti de Araújo

• Use of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide (P-15) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans Ana L. Eto,* Julio C. Joly,* Marjorie Jeffcoat,† Ney S. de Araújo,‡ Vera C. de Araújo,§ and Patricia R. Cury* *Department of Periodontics, São Leopoldo Mandic Dental Research Center, Campinas, SP, Brazil.

  †Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA.

  ‡Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.

  §Department of Oral Pathology, São Leopoldo Mandic Dental Research Center.

  Correspondence: Dr. Patricia R. Cury, São Leopoldo Mandic Dental Research Center, Rua Abolição, 1827, Ponte Preta, Campinas, SP 13045-610, Brazil. Fax: 55-19-3237-3611; e-mail: patcury@yahoo.com.

  Background: This study compared clinical and radiographic findings for the treatment of Class II furcation defects in human mandibular molars using anorganic bovine-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) or open flap debridement (OFD).

  Methods: Twelve subjects showing two comparable Class II furcation defects in their mandibular molars were enrolled. The defects in each subject were assigned randomly to the test (ABM/P-15) or the control (OFD) group. Clinical measurements and standardized radiographs were taken at baseline and 6 to 7 months after surgery.

  Results: There were no statistically significant differences between the test and control groups for any clinical or radiographic parameter (P >0.05). On comparing the baseline and final measurements, the gain in horizontal clinical attachment level and reduction in gingival recession were significant only in the test group (P ≤0.02), whereas the gain in the vertical clinical attachment level was significant in both groups (P ≤0.04). In the test group, four of 12 sites showed complete closure, and five showed partial closure; in the control group, three defects showed complete closure, and four showed partial closure (P = 0.42). Subtraction radiography revealed similar gains in bone height and increases in mean bone density with both treatments (P >0.05).

  Conclusions: ABM/P-15 yielded favorable results in the treatment of Class II furcation defects over a 6-month evaluation period; however, there was no difference compared to OFD. Further studies using a larger sample size are needed to confirm the present findings.

  KEYWORDS: Clinical trial, furcation defect, periodontal regeneration, periodontitis Cited by Gustavo Avila-Ortiz, Juan G. De Buitrago and Michael S. Reddy. (2015) Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop. Journal of Periodontology 86:2-s, S108-S130.

  Online publication date: 1-Feb-2015.

  Abstract | Full Text | PDF (888 KB) | PDF Plus (881 KB) Carlos A. Nazareth and Patricia R. Cury. (2011) Use of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide (P-15) in the Treatment Isolated Class I Gingival Recession of Defects: A Pilot Study. Journal of Periodontology 82:5, 700-707.

  Online publication date: 1-May-2011.

  Abstract | Full Text | PDF (733 KB) | PDF Plus (584 KB) Ihab El-Madany, Hany Emam and Mohamed Sharawy. (2011) Comparison of Cellular Response to Anorganic Bone Matrix/Cell Binding Peptide and Allogenic Cranial Bone after Sinus Augmentation in Rhesus Monkeys. Journal of Oral Implantology, 110220121911010.

  Online publication date: 18-Feb-2011.

  CrossRef Fa-Ming Chen, Jing Zhang, Min Zhang, Ying An, Fang Chen and Zhi-Fen Wu. (2010) A review on endogenous regenerative technology in periodontal regenerative medicine. Biomaterials 31, 7892-7927.

  Online publication date: 1-Nov-2010.

  CrossRef Adrian Kasaj, Bernd Röhrig, Christoph Reichert and Brita Willershausen. (2008) Clinical evaluation of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (P-15) in the treatment of human infrabony defects. Clinical Oral Investigations 12, 241-247.

  Online publication date: 1-Sep-2008.

  CrossRef