Microbiologic Changes Following Administration of Locally Delivered Doxycycline in Smokers: A 15-Month Follow-Up

• Autores: Enilson Antonio Sallum, Clay B. Walker, Luciana M. Shaddox, Denise Carleto Andia, Marcio Zaffalon Casati, Francisco Humberto Nociti, Jennifer Gollwitzer
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 78, Nº. 11, 2007, págs. 2143-2149
• Idioma: inglés
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• Resumen

  • Microbiologic Changes Following Administration of Locally Delivered Doxycycline in Smokers: A 15-Month Follow-Up Luciana M. Shaddox,* Denise Carleto Andia,† Marcio Zaffalon Casati,† Francisco Humberto Nociti Jr.,† Enilson Antonio Sallum,† Jennifer Gollwitzer,‡ and Clay B. Walker‡ *Department of Periodontology, School of Dentistry, University of Florida, Gainesville, FL.

    †Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, State University of Campinas, São Paulo, SP, Brazil.

    ‡Department of Oral Biology, College of Dentistry, University of Florida.

    Correspondence: Dr. Luciana M. Shaddox, Department of Periodontology, School of Dentistry, University of Florida, 1600 Archer Rd., Dental Tower, Room D10-6B, Gainesville, FL 32610. Fax: 352/392-5899; e-mail: lmachion@dental.ufl.edu.

    Background: Additional clinical benefits have been reported with the use of locally delivered antimicrobials in the treatment of smokers; however, long-term changes in the subgingival microbiota following the use of these drugs in smokers have not been documented. The aim of this study was to evaluate long-term microbiologic changes following locally delivered doxycycline in the treatment of smokers.

    Methods: Sixteen smokers with chronic periodontitis presenting a minimum of four pockets (probing depth ≥5 mm) were selected. Patients were assigned randomly to receive scaling and root planing (SRP) or SRP and local doxycycline (SRP-D). Patients were treated at baseline and 12 months. Subgingival plaque samples were collected at baseline; 3, 6, and 12 months; and 45 and 90 days following retreatment. Polymerase chain reaction and DNA–DNA hybridization analyses were performed to detect the presence of selected periodontal pathogens.

    Results: The reduction in the number of sites positive for Porphyromonas gingivalis and Tannerella forsythia (previously T. forsythensis) was statistically significant for SRP-D at 3 months (68% and 41.3%, respectively) and for SRP at 6 months (75% and 52%, respectively) following treatment. The SRP group showed a greater frequency of P. gingivalis than the SRP-D group at 3 months (58% and 25%, respectively). There also was a greater reduction in the frequency of P. gingivalis at 3 months following retreatment with SRP-D compared to SRP (47% and 8%, respectively).

    Conclusion: In smokers, adjunctive local doxycycline resulted in a greater reduction in the frequency of P. gingivalis following initial and supportive therapy compared to conventional treatment.

    KEYWORDS: Doxycycline, microbiology, periodontal disease, smoking, therapy Cited by Marc Lauenstein, Marion Kaufmann and G. Rutger Persson. (2013) Clinical and microbiological results following nonsurgical periodontal therapy with or without local administration of piperacillin/tazobactam. Clinical Oral Investigations 17, 1645-1660.

    Online publication date: 1-Sep-2013.

    CrossRef Ibrahimu Mdala, Ingar Olsen, Anne D. Haffajee, Sigmund S. Socransky, Birgitte Freiesleben de Blasio and Magne Thoresen. (2013) Multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. Journal of Oral Microbiology 5.

    Online publication date: 9-Jul-2013.

    CrossRef Jacob Shiloah, Paul S. Bland, Mark Scarbecz, Mark R. Patters, Sidney H. Stein and David A. Tipton. (2013) The effect of long-term aspirin intake on the outcome of non-surgical periodontal therapy in smokers: a double-blind, randomized pilot study. Journal of Periodontal Research, n/a-n/a.

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    CrossRef Paulo Nelson-Filho, Karla Orfelina Carpio-Horta, Marcela Cristina Damião Andrucioli, Magda Feres, Raquel Assed Bezerra da Silva, Francisco Wanderley Garcia Paula-Silva and Fábio Lourenço Romano. (2012) Molecular detection of Aggregatibacter actinomycetemcomitans on metallic brackets by the checkerboard DNA-DNA hybridization technique. American Journal of Orthodontics and Dentofacial Orthopedics 142, 481-486.

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    CrossRef Esha Agarwal, A.R. Pradeep, Pavan Bajaj and Savitha B. Naik. (2012) Efficacy of Local Drug Delivery of 0.5% Clarithromycin Gel as an Adjunct to Non-Surgical Periodontal Therapy in the Treatment of Current Smokers With Chronic Periodontitis: A Randomized Controlled Clinical Trial. Journal of Periodontology 83:9, 1155-1163.

    Online publication date: 1-Sep-2012.

    Abstract | Full Text | PDF (507 KB) | PDF Plus (514 KB) Sampath K. Rao, Swati Setty, Anirudh B. Acharya and Srinath L. Thakur. (2011) Efficacy of locally-delivered doxycycline microspheres in chronic localized periodontitis and on Porphyromonas gingivalis. Journal of Investigative and Clinical Dentistry, no-no.

    Online publication date: 1-Dec-2011.

    CrossRef Hassan Al Hulami, Nadir Babay, Fatin Awartani and Sukumaran Anil. (2011) The effect of locally delivered doxycycline as an adjunctive therapy to scaling and root planing in smokers. The Saudi Dental Journal 23, 143-148.

    Online publication date: 1-Jul-2011.

    CrossRef Ti-Sun Kim, Sang-Heon Lee, Peter Eickholz, Holger Zimmer and Chong-Kwan Kim. (2009) Systemic detection of doxycycline after local administration. Acta Odontologica Scandinavica 67, 289-296.

    Online publication date: 1-Jan-2009.