Effect of Periodontal Therapy on Pregnancy Outcome in Women Affected by Periodontitis

• Autores: Fouzia Tarannum, Mohamed Faizuddin
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 78, Nº. 11, 2007, págs. 2095-2103
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Effect of Periodontal Therapy on Pregnancy Outcome in Women Affected by Periodontitis Fouzia Tarannum* and Mohamed Faizuddin* *Department of Periodontics, M.R. Ambedkar Dental College and Hospital, Bangalore, Karnataka, India.

    Correspondence: Dr. Fouzia Tarannum, 79/13, 5th Cross, Pillanna Garden, 1st Stage, Bangalore, Karnataka 560084, India. E-mail: dr_fouzta@indiatimes.com.

    Background: There is convincing evidence to suggest that infections affecting the mother during pregnancy may produce alterations in the normal cytokine- and hormone-regulated gestation, which could result in preterm labor, premature rupture of membranes, and preterm birth (PTB). Studies in the late 1990s associated periodontitis with preterm low birth weight (PLBW) deliveries, and this may have similar pathogenic mechanisms as other maternal infections. This study determined the effect of non-surgical periodontal therapy on pregnancy outcome.

    Methods: A total of 200 pregnant women with periodontitis were randomly assigned to treatment and control groups. Detailed data about previous and current pregnancies were obtained. All women received a full-mouth periodontal examination, including oral hygiene index-simplified, bleeding index, and clinical attachment level. The women in the treatment group received non-surgical periodontal therapy during the gestational period, and those in the control group received periodontal treatment after delivery. Periodontal therapy included plaque control instructions and scaling and root planing performed under local anesthesia. The outcome measures assessed were gestational age and birth weight of the infant. PTB was recorded when delivery occurred at <37 weeks of gestation, and low birth weight (LBW) was recorded when the infant weighed <2,500 g.

    Results: There were 53 PTBs in the treatment group and 68 PTBs in the control group. Twenty-six LBW infants were recorded in the treatment group, and 48 LBW infants were noted in the control group. The mean gestational ages were 33.8 ± 2.8 weeks and 32.7 ± 2.8 weeks in the treatment and control groups, respectively. The difference was statistically significant at P <0.006. The mean birth weight was 2,565.3 ± 331.2 g in the treatment group and 2,459.6 ± 380.7 g in the control group, with the difference being statistically significant at P <0.044. A multiple regression model showed a significant effect of periodontal treatment on birth outcomes.

    Conclusions: Non-surgical periodontal therapy can reduce the risk for preterm births in mothers who are affected by periodontitis. Additional multicentered, randomized, controlled clinical trials are required to confirm this link between periodontitis and PLBW.

    KEYWORDS: Low birth weight, periodontitis, preterm, randomized controlled clinical trial Cited by Néstor J. López, Sergio Uribe and Benjamín Martinez. (2015) Effect of periodontal treatment on preterm birth rate: a systematic review of meta-analyses. Periodontology 2000 67:10.1111/prd.2015.67.issue-1, 87-130.

    Online publication date: 1-Feb-2015.

    CrossRef Maninder Kaur, Maria L. Geisinger, Nicolaas C. Geurs, Russell Griffin, Philip J. Vassilopoulos, Lisa Vermeulen, Sandra Haigh and Michael S. Reddy. (2014) Effect of Intensive Oral Hygiene Regimen During Pregnancy on Periodontal Health, Cytokine Levels, and Pregnancy Outcomes: A Pilot Study. Journal of Periodontology 85:12, 1684-1692.

    Online publication date: 1-Dec-2014.

    Abstract | Full Text | PDF (487 KB) | PDF Plus (528 KB) Marjorie K. Jeffcoat, Robert L. Jeffcoat, Nipul Tanna and Samuel H. Parry. (2014) Association of a Common Genetic Factor, PTGER3, With Outcome of Periodontal Therapy and Preterm Birth. Journal of Periodontology 85:3, 446-454.

    Online publication date: 1-Mar-2014.

    Abstract | Full Text | PDF (1327 KB) | PDF Plus (697 KB) Crispian Scully. 2014. Age and gender issues. Scully's Medical Problems in Dentistry, 627-651.

    CrossRef B. V. Ramesh Reddy, S. Tanneeru and V. K. Chava. (2014) The effect of phase-I periodontal therapy on pregnancy outcome in chronic periodontitis patients. Journal of Obstetrics & Gynaecology 34, 29-32.

    Online publication date: 1-Jan-2014.

    CrossRef Monali Shah, Arti Muley and Prasad Muley. (2013) Effect of nonsurgical periodontal therapy during gestation period on adverse pregnancy outcome: a systematic review. Journal of Maternal-Fetal and Neonatal Medicine 26, 1691-1695.

    Online publication date: 1-Nov-2013.

    CrossRef B. Condylis, H. Le Borgne, J. Demoersman, G. Campard, H.-J. Philippe and A. Soueidan. (2013) Intérêt du dépistage et du traitement des maladies parodontales chez la femme enceinte : revue de la littérature. Journal de Gynécologie Obstétrique et Biologie de la Reproduction 42, 511-517.

    Online publication date: 1-Oct-2013.

    CrossRef Bryan S. Michalowicz, Anders Gustafsson, Vivek Thumbigere-Math and Kåre Buhlin. (2013) The effects of periodontal treatment on pregnancy outcomes. Journal of Periodontology 84:4-s, S195-S208.

    Online publication date: 1-Apr-2013.

    Abstract | PDF (588 KB) | PDF Plus (699 KB) Bryan S. Michalowicz, Anders Gustafsson, Vivek Thumbigere-Math and Kåre Buhlin. (2013) The effects of periodontal treatment on pregnancy outcomes. Journal of Clinical Periodontology 40:10.1111/jcpe.2013.40.issue-s14, S195-S208.

    Online publication date: 1-Apr-2013.

    CrossRef Gary C. Armitage. (2013) Bi-directional relationship between pregnancy and periodontal disease. Periodontology 2000 61, 160-176.

    Online publication date: 1-Feb-2013.

    CrossRef T. Fiorini, C. Susin, J. M. da Rocha, P. Weidlich, P. Vianna, C. H. C. Moreira, J. A. Bogo Chies, C. K. Rösing and R. V. Oppermann. (2013) Effect of nonsurgical periodontal therapy on serum and gingival crevicular fluid cytokine levels during pregnancy and postpartum. Journal of Periodontal Research 48:10.1111/jre.2012.48.issue-1, 126-133.

    Online publication date: 1-Feb-2013.

    CrossRef Ashok Kumar, Minu Basra, Nargis Begum, Vigya Rani, Sudha Prasad, Arundeep Kaur Lamba, Mahesh Verma, Sarita Agarwal and Shashi Sharma. (2013) Association of maternal periodontal health with adverse pregnancy outcome. Journal of Obstetrics and Gynaecology Research 39:10.1111/jog.2013.39.issue-1, 40-45.

    Online publication date: 1-Jan-2013.

    CrossRef Arthur J. Kim, Alexander J. Lo, Deborah A. Pullin, Darneesh S. Thornton-Johnson and Nadeem Y. Karimbux. (2012) Scaling and Root Planing Treatment for Periodontitis to Reduce Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Periodontology 83:12, 1508-1519.

    Online publication date: 1-Dec-2012.

    Abstract | Full Text | PDF (1612 KB) | PDF Plus (910 KB) | Supplementary Material Alessandra N. Guimarães, Agustín Silva-Mato, Fernanda M. Siqueira, Renata M. Cyrino, Luís O. M. Cota and Fernando O. Costa. (2012) Very low and low birth weight associated with maternal periodontitis. Journal of Clinical Periodontology 39:10.1111/jcpe.2012.39.issue-11, 1024-1031.

    Online publication date: 1-Nov-2012.

    CrossRef S. Corbella, M. Del Fabbro, S. Taschieri and L. Francetti. (2012) Periodontal disease and adverse pregnancy outcomes: a systematic review. Italian Oral Surgery 11, 132-146.

    Online publication date: 1-Sep-2012.

    CrossRef Patricia Weidlich, Carlos Heitor C. Moreira, Tiago Fiorini, Marta L. Musskopf, José M. Rocha, Maria Lucia R. Oppermann, Anne M. Aass, Per Gjermo, Cristiano Susin, Cassiano K. Rösing and Rui V. Oppermann. (2012) Effect of nonsurgical periodontal therapy and strict plaque control on preterm/low birth weight: a randomized controlled clinical trial. Clinical Oral Investigations.

    Online publication date: 31-Jan-2012.

    CrossRef Joan Otomo-Corgel. 2012. Periodontal Therapy in the Female Patient. Carranza's Clinical Periodontology, 412-421.

    CrossRef S. Nagarakanti. (2012) Knowledge, attitude and practice towards periodontal diseases among gynaecologists: A pilot study. Journal of Obstetrics & Gynaecology 32, 62-63.

    Online publication date: 1-Jan-2012.

    CrossRef Sindhu K. Srinivas and Samuel Parry. (2011) Periodontal Disease and Pregnancy Outcomes: Time to Move On?. Journal of Women's Health, 111012090741005.

    Online publication date: 12-Oct-2011.

    CrossRef Leandro Chambrone, Cláudio Mendes Pannuti, Mariana Rocha Guglielmetti and Luiz Armando Chambrone. (2011) Evidence grade associating periodontitis with preterm birth and/or low birth weight: II. A systematic review of randomized trials evaluating the effects of periodontal treatment. Journal of Clinical Periodontology 38:10.1111/jcpe.2011.38.issue-10, 902-914.

    Online publication date: 1-Oct-2011.

    CrossRef Marjorie Jeffcoat, Samuel Parry, Robert W. Gerlach and Matthew J. Doyle. (2011) Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population. American Journal of Obstetrics and Gynecology 205, 382.e1-382.e6.

    Online publication date: 1-Oct-2011.

    CrossRef Xu Xiong, Pierre Buekens, Robert L. Goldenberg, Steven Offenbacher and Xu Qian. (2011) Optimal timing of periodontal disease treatment for prevention of adverse pregnancy outcomes: before or during pregnancy?. American Journal of Obstetrics and Gynecology 205, 111.e1-111.e6.

    Online publication date: 1-Aug-2011.

    CrossRef Ajesh George, Simin Shamim, Maree Johnson, Shilpi Ajwani, Sameer Bhole, Anthony Blinkhorn, Sharon Ellis and Karen Andrews. (2011) Periodontal treatment during pregnancy and birth outcomes: a meta-analysis of randomised trials. International Journal of Evidence-Based Healthcare 9:10.1111/jbr.2011.9.issue-2, 122-147.

    Online publication date: 1-Jun-2011.

    CrossRef Nadia Kawar and Sahar Alrayyes. (2011) Periodontitis in Pregnancy: The Risk of Preterm Labor and Low Birth Weight. Disease-a-Month 57, 192-202.

    Online publication date: 1-Apr-2011.

    CrossRef Haritha Avula and Jayakumar Avula. (2011) Periodontal Infections and Adverse Pregnancy Outcomes: The Oral Health—Fetal Connection. Journal of Gynecologic Surgery, 110119111308011.

    Online publication date: 19-Jan-2011.

    CrossRef M Jeffcoat, S Parry, M Sammel, B Clothier, A Catlin and G Macones. (2011) Periodontal infection and preterm birth: successful periodontal therapy reduces the risk of preterm birth. BJOG: An International Journal of Obstetrics & Gynaecology 118:10.1111/bjo.2010.118.issue-2, 250-256.

    Online publication date: 1-Jan-2011.

    CrossRef Maryanne F. Lachat, Antoinette Lipani Solnik, Anjali D. Nana and Tracie L. Citron. (2011) Periodontal Disease in Pregnancy. The Journal of Perinatal & Neonatal Nursing 25, 312-319.

    Online publication date: 1-Jan-2011.

    CrossRef Mariana Fampa Fogacci, Mario Vianna Vettore and Anna Thereza Thomé Leão. (2011) The Effect of Periodontal Therapy on Preterm Low Birth Weight. Obstetrics & Gynecology 117, 153-165.

    Online publication date: 1-Jan-2011.

    CrossRef D. A. Albert, M. D. Begg, H. F. Andrews, S. Z. Williams, A. Ward, M. Lee Conicella, V. Rauh, J. L. Thomson and P. N. Papapanou. (2011) An Examination of Periodontal Treatment, Dental Care, and Pregnancy Outcomes in an Insured Population in the United States. American Journal of Public Health 101, 151-156.

    Online publication date: 1-Jan-2011.

    CrossRef Elizabeth Shira Davenport. (2010) Preterm low birthweight and the role of oral bacteria. Journal of Oral Microbiology 2.

    Online publication date: 21-Dec-2010.

    CrossRef Isaac S. Gomes-Filho, Simone S. Cruz, Maria da Conceiçao N. Costa, Johelle S. Passos, Eneida M.M. Cerqueira, Fábio P. Sampaio, Eliesita C. Pereira and Lituânia F. Miranda. (2010) Periodontal Therapy and Low Birth Weight: Preliminary Results From an Alternative Methodologic Strategy. Journal of Periodontology 81:12, 1725-1733.

    Online publication date: 1-Dec-2010.

    Abstract | Full Text | PDF (493 KB) | PDF Plus (523 KB) Naira Roland Matevosyan. (2010) Periodontal disease and perinatal outcomes. Archives of Gynecology and Obstetrics.

    Online publication date: 1-Dec-2010.

    CrossRef A. Uppal, S. Uppal, A. Pinto, M. Dutta, S. Shrivatsa, V. Dandolu and M. Mupparapu. (2010) The Effectiveness of Periodontal Disease Treatment During Pregnancy in Reducing the Risk of Experiencing Preterm Birth and Low Birth Weight: A Meta-analysis. Journal of the American Dental Association 141, 1423-1434.

    Online publication date: 1-Dec-2010.

    CrossRef Alcione Maria Soares Dutra Oliveira, Peterson Antonio Dutra Oliveira, Luís Otávio Miranda Cota, Claúdia Silami Magalhães, Allyson Nogueira Moreira and Fernando Oliveira Costa. (2010) Periodontal therapy and risk for adverse pregnancy outcomes. Clinical Oral Investigations.

    Online publication date: 22-May-2010.

    CrossRef Simone S. Cruz, Maria da Conceição N. Costa, Isaac S. Gomes-Filho, Maurício L. Barreto, Carlos Antônio S.T. dos Santos, Ângela Guimarães Martins, Johelle de S. Passos, Camila Oliveira T. de Freitas, Fábio P. Sampaio and Eneida de M.M. Cerqueira. (2010) Periodontal therapy for pregnant women and cases of low birthweight: An intervention study. Pediatrics International 52:10.1111/ped.2010.52.issue-1, 57-64.

    Online publication date: 1-Feb-2010.

    CrossRef Simone S. Cruz, Maria da Concei����o N. Costa, Isaac S. Gomes-Filho, Edson J. C. Rezende, Maur��cio L. Barreto, Carlos Ant��nio S. T. dos Santos, Maria Isabel P. Vianna, Johelle S. Passos and Eneida M. M. Cerqueira. (2009) Contribution of periodontal disease in pregnant women as a risk factor for low birth weight. Community Dentistry and Oral Epidemiology 37:10.1111/com.2009.37.issue-6, 527-533.

    Online publication date: 1-Dec-2009.

    CrossRef CLZ Vieira and B Caramelli. (2009) The history of dentistry and medicine relationship: could the mouth finally return to the body?. Oral Diseases 15:10.1111/odi.2009.15.issue-8, 538-546.

    Online publication date: 1-Nov-2009.

    CrossRef Steven Offenbacher, James D. Beck, Heather L. Jared, Sally M. Mauriello, Luisto C. Mendoza, David J. Couper, Dawn D. Stewart, Amy P. Murtha, David L. Cochran, Donald J. Dudley, Michael S. Reddy, Nicolaas C. Geurs and John C. Hauth. (2009) Effects of Periodontal Therapy on Rate of Preterm Delivery. Obstetrics & Gynecology 114, 551-559.

    Online publication date: 1-Sep-2009.

    CrossRef Aura Heimonen, Sok-Ja Janket, Risto Kaaja, Leland K. Ackerson, Preetika Muthukrishnan and Jukka H. Meurman. (2009) Oral Inflammatory Burden and Preterm Birth. Journal of Periodontology 80:6, 884-891.

    Online publication date: 1-Jun-2009.

    Abstract | Full Text | PDF (489 KB) | PDF Plus (518 KB) R. A. Seymour. (2009) Is gum disease killing your patient?. BDJ 206, 551-552.

    Online publication date: 23-May-2009.

    CrossRef Nikolaos P. Polyzos, Ilias P. Polyzos, Davide Mauri, Spyridon Tzioras, Maria Tsappi, Ivan Cortinovis and Giovanni Casazza. (2009) Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials. American Journal of Obstetrics and Gynecology 200, 225-232.

    Online publication date: 1-Mar-2009.

    CrossRef Gernot Wimmer and Bruce L. Pihlstrom. (2008) A critical assessment of adverse pregnancy outcome and periodontal disease. Journal of Clinical Periodontology 35:10.1111/cpe.2008.35.issue-s8, 380-397.

    Online publication date: 1-Sep-2008.

    CrossRef Peilei Jiang, Eric P. Bargman, Nancy A. Garrett, Andrea DeVries, Steve Springman and Sheila Riggs. (2008) A Comparison of Dental Service Use Among Commercially Insured Women in Minnesota Before, During and After Pregnancy. The Journal of the American Dental Association 139, 1173-1180.

    Online publication date: 1-Sep-2008.