Nifedipine Intake Increases the Risk for Periodontal Destruction in Subjects With Type 2 Diabetes Mellitus
- Autores: Xiao Li, Qingxian Luan, Xingyu Wang, Yueqin Sha, Lu He, Caifang Cao, Lijian Jin
- Localización: Journal of periodontology, ISSN 0022-3492, Vol. 79, Nº. 11, 2008, págs. 2054-2059
- Idioma: inglés
- Enlaces
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Resumen
Background: This study investigated the possible association of nifedipine (NIF) intake and diabetes mellitus (DM) with periodontal destruction.
Methods: A group of Chinese subjects (N = 1,083, age: 63 ± 8.7 years) were screened. Three hundred fifty-eight non-smokers with hypertension were selected for the study and were grouped based on DM status as non-DM and DM groups, DM(−) and DM(+) respectively. NIF(+) and NIF(−) indicated NIF intake or not. The groups were further divided: NIF(−)/DM(−) (n = 135); NIF(+)/DM(−) (n = 108); NIF(−)/DM(+) (n = 64); and NIF(+)/DM(+) (n = 51). The periodontal conditions in anterior teeth were assessed using plaque index, sulcus bleeding index, clinical attachment loss (AL), probing depth (PD), and the number of missing teeth.
Results: Using analysis of covariance, NIF intake was associated with mean PD and extent of PD ≥4 mm in the non-DM and DM groups. The subjects in the NIF(+)/DM(+) subgroup showed greater mean AL and percentage of sites with AL ≥5 mm and AL ≥7 mm than those in NIF(−)/DM(+) subgroup, whereas no significant difference existed between subjects in NIF(−)/DM(−) and NIF(+)/DM(−) subgroups. The NIF(+)/DM(+) subgroup exhibited a greater percentage of sites with AL ≥5 mm (35.5%) compared to the other three subgroups (24.7% for NIF[−]/DM[−], P = 0.004; 25.0% for NIF[+]/DM[−], P = 0.007; and 25.2% for NIF[−]/DM[+], P = 0.016). Logistic regression analysis showed that the NIF(+)/DM(+) subgroup had a significantly higher risk for having >10% of sites with AL ≥5 mm compared to the NIF(−)/DM(−) subgroup (odds ratio [OR] = 2.9; 95% confidence interval [CI]: 1.2 to 7.4; P = 0.022), the NIF(+)/DM(−) subgroup (OR = 3.1; 95% CI: 1.2 to 8.1; P = 0.020), and the NIF(−)/DM(+) subgroup (OR = 5.1; CI: 1.8 to 14.3; P = 0.002).
Conclusion: NIF intake may increase the risk for periodontal destruction in patients with type 2 DM.
