NMR Kinetics of the SN2 Reaction between BuBr and I–: An Introductory Organic Chemistry Laboratory Exercise

• Autores: T. Andrew Mobley
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 92, Nº 3, 2015, págs. 534-537
• Idioma: inglés
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• Resumen

  • A simple organic chemistry experiment is described that investigates the kinetics of the reaction between 1-bromobutane (BuBr) and iodide (I–) as followed by observing the disappearance of BuBr and the appearance of 1-iodobutane (BuI) using 1H NMR spectroscopy. In small groups of three to four, students acquire data to examine the concentration-dependence of both the organic substrate and the nucleophile under pseudo-first-order and second-order conditions. After data processing, students analyze three data sets (one second-order experiment, and two first-order experiments with different concentrations of iodide) using an electronic spreadsheet. Students discuss the experimentally determined rate law, comparing it to that predicted for this SN2 reaction.