Online Article: A Novel Approach for Skin Rejuvenation by Regenerative Medicine: Delivery of Stem Cell-Derived Growth Factors Through an Iontophoretic System

• Autores: Minoru Ueda
• Localización: The International Journal of Oral & Maxillofacial Implants, ISSN-e 0882-2786, Vol. 29, Nº. 1, 2014, págs. 59-65
• Idioma: inglés
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• Resumen

  • Purpose: It was hypothesized that mesenchymal stem cell (MSC)-derived growth factor applied by iontophoretic transdermal delivery might improve ultraviolet beam (UVB)-induced photoaged skin. This experimental study was performed to confirm this hypothesis.

    Materials and Methods: Photoaged skin was induced in nude rat after an 8-week regimen of UVB irradiation, and an MSC-conditioned medium (MSC-CM) was conducted by an iontophoretic transdermal transport system. The effect of iontophoresis with MSC-CM was evaluated by replica method and measurement of the hyaluronic acid level in the dermis after treatment.

    Results: MSC-CM conducted by iontophoresis significantly reduced all parameters for wrinkles and increased hyaluronic acid in the dermis.

    Conclusion: MSC-CM application by iontophoresis can be considered as a supplemental treatment to the methods for skin rejuvenation.