Persistence of Mild to Moderate Atopic Dermatitis

• Autores: Jacob S. Margolis, Katrina Abuabara, Warren Bilker, David J. Margolis
• Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 150, Nº. 6, 2014, págs. 593-600
• Idioma: inglés
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• Resumen

  • Importance Atopic dermatitis (AD) is a common illness of childhood.

    Objective To evaluate the natural history of AD and determine the persistence of symptoms over time.

    Design, Setting, and Participants A cross-sectional and cohort study of a nation-wide long-term registry of children with AD enrolled in the Pediatric Eczema Elective Registry (PEER).

    Main Outcomes and Measures Self-reported outcome of whether a child's skin was AD symptom-free for 6 months at 6-month intervals.

    Results A total of 7157 patients were enrolled in the PEER study for a total of 22?550 person-years. At least 2 years of follow-up were observed for 4248 children and at least 5 years of follow-up were observed for 2416 children. Multiple demographic and exposure variables were associated with more persistent AD. At every age (ie, 2-26 years), more than 80% of PEER participants had symptoms of AD and/or were using medication to treat their AD. It was not until age 20 years that 50% of patients had at least 1 lifetime 6-month symptom- and treatment-free period.

    Conclusions and Relevance Based on this large longitudinal cohort study, symptoms associated with AD seem to persist well into the second decade of a child's life and likely longer. Atopic dermatitis is probably a life-long illness.