Clinical Presentations of Severe Cutaneous Drug Reactions in HIV-Infected Africans

• Autores: Rannakoe J. Lehloenya, Mahlatse Kgokolo
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 32, Nº. 2, 2014 (Ejemplar dedicado a: African Skin and Hair Disorders), págs. 227-235
• Idioma: inglés
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• Resumen

  • Sub-Saharan Africa is the epicenter of the HIV pandemic and HIV-infected people are more susceptible to inflammatory dermatoses, infections, and drug eruptions. Many of the drugs used for HIV-associated opportunistic infections are associated with a higher incidence of drug-related toxicities and drug interactions. This article discusses the epidemiology, pharmacogenetics, and clinical features of idiosyncratic drug reactions in HIV-infected Africans. Special considerations in this population, including immune reconstitution inflammatory syndrome, multiple drug hypersensitivity syndrome, drug reactions in pregnancy, drug rechallenge in lichenoid drug eruptions, and anxiety/depression after cutaneous adverse drug reactions, are also briefly discussed.