Alteration in Pancreatic Islet Function in Human Immunodeficiency Virus

• Autores: Steen B. Haugaard
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 43, Nº. 3, 2014, págs. 697-708
• Idioma: inglés
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• Resumen

  • Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.