Arterial stiffness in kidney transplantation: a single center case-control study comparing belatacept versus calcineurin inhibitor immunosuppressive based regimen
- Autores: Edoardo Melilli, Oriol Bestard Matamoros, Anna Manonelles Montero, Neus Sala, Richard Mast Vilaseca, Josep María Grinyó, Josep Maria Cruzado Garrit
- Localización: Nefrología: publicación oficial de la Sociedad Española de Nefrología, ISSN 0211-6995, Vol. 35, Nº. 1, 2015, págs. 58-65
- Idioma: inglés
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Resumen
Arterial stiffness is nowadays a well-accepted predictor of car - diovascular mortality in general population; as well as in kidney transplant recipient population. The femoral-carotid pulse wave velocity (cf-PWV) is the widest used method to assess the arterial stiffness. The aim of this study was to test whether CNI-free im - munosuppression based on belatacept was associated with lower cf-PWV, as a surrogate marker of arterial stiffness, than CNI. This was a retrospective case-control study. We included all the cas - es treated with belatacept as a maintenance immunosuppression in our center (n=20). An appropriate control group of patients (n=20) treated with CNI was selected to achieve match for key factors associated with arterial stiffness. After a follow-up of 5 years after transplantation, the Belatacept group had a reduced prevalence of patients with a cf-PWV higher than 8.1m/s (50% in BLC vs. 25% in CNI, p=0.08). At multivariate logistic regression analysis, the risk of high cf-PWV was correlated with age (OR 1.24;
p<0.03) and renal resistive index (OR 1.25; p<0.05). Belatacept treat - ment was associated with a significant reduction in risk of cf-PWV (OR 0.008; P=0.045). Belatacept-based maintenance immunosup - pression could improve kidney transplant recipient�s survival by reducing cardiovascular events related to stiffness
