A Knoevenagel Initiated Annulation Reaction Using Room Temperature or Microwave Conditions.

• Autores: A. Gilbert Cook
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 84, Nº 9, 2007, págs. 1477-1479
• Idioma: inglés
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• Resumen

  • An experiment is presented that has the student execute a Knoevenagel initiated annulation reaction. The reaction can be carried out either through use of a microwave reactor or by allowing the mixture to stand at room temperature for two days. The student is then challenged to identify the reaction product through a guided prelab exercise of the synthesis of the Hagemann ester, and then through GC�MS, NMR, and IR spectra of the product. The stereochemistry of the product is determined through the NMR spectrum and the Karplus curve. The student is required to write a mechanism for the reaction.