Resumen de Assigning the NMR Spectrum of Glycidol: An Advanced Organic Chemistry Exercise.

Eric Helms, Nicholas Arpaia, Melissa Widener

• This exercise combines conformational analysis and 1-D and 2-D NMR spectroscopy to correctly assign the proton and carbon NMR spectra of 2,3-epoxy-1-propanol (glycidol). In the process, students learn how to read DEPT-135, HETCOR, and COSY spectra. One set of diastereotopic protons is assigned using dihedral angles and the Karplus relationship. The assignment of the other set of diastereotopic protons requires that conformational modeling be done to complete the assignment of protons to signals.