Assessing the impact of early detection biases on breast cancer survival of Catalan women

• Autores: Albert Roso Llorach, Carles Forné Izquierdo, Francesc Macià Guilà, Jaume Galceran Padrós, Rafael Marcos Gragera, Montserrat Rué Monné
• Localización: Sort: Statistics and Operations Research Transactions, ISSN 1696-2281, Vol. 38, Nº. 2, 2014, págs. 139-160
• Idioma: inglés
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• Resumen

  • Survival estimates for women with screen-detected breast cancer are affected by biases specific to early detection. Lead-time bias occurs due to the advance of diagnosis, and length-sampling bias because tumors detected on screening exams are more likely to have slower growth than tumors symptomatically detected. Methods proposed in the literature and simulation were used to assess the impact of these biases. If lead-time and length-sampling biases were not taken into account, the median survival time of screen-detected breast cancer cases may be overestimated by 5 years and the 5-year cumulative survival probability by between 2.5 to 5 percent units.