Long non-coding RNAs in the regulation of the immune response

• Autores: James A. Heward, Mark A. Lindsay
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 9, 2014, págs. 408-419
• Idioma: inglés
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• Resumen

  • It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of lncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These lncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein�protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and lncRNA biology.