An antibody tag-team: driving neutralization through escape

• Autores: Galit Alter, Margaret E. Ackerman
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 9, 2014, págs. 403-405
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • HIV rapidly mutates to escape antibody detection, and B cells counter this mutation by continual evolution to restore recognition, serendipitously resulting in the evolution of neutralizing activity in a fraction of infected individuals. A recent Cell paper describes how antibody repertoires stochastically collaborated, shaping the viral swarm and utilizing viral immune evasion to their advantage.