Inflammatory interference of memory formation

• Autores: Akshay T. Krishnamurty, Marion Pepper
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 8, 2014, págs. 355-357
• Idioma: inglés
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• Resumen

  • CD8+ memory T cells are critical for immunity against intracellular pathogens. Epidemiological evidence demonstrates that bystander infection can impact immune responses to co-infection or vaccination. A recent paper in Immunity demonstrates that persistent bystander inflammation can negatively impact CD8+ T cell effector to memory transition and protection from subsequent infection.