Implications of cytokine genes in allergic asthma

• J. Padrón-Morales ^[1] ; V. García-Solaesa ^[1] ; M. Isidoro-García ^[2] ; L. Hernández-Hernández ^[1] ; A. García-Sánchez ^[1] ; G. Hincapié-López ; F. Lorente-Toledano ^[1] ; I. Dávila ^[1] ; C. Sanz ^[2]
  1. [1] Department of Immunoallergy, Salamanca University Hospital
  2. [2] Biomedical Research Institute of Salamanca, IBSAL, Salamanca
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 42, Nº. 6, 2014, págs. 603-608
• Idioma: inglés
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• Resumen

  • Asthma is a complex disease involving numerous mediator molecules and effector cells, in combination with a range of environmental determining factors. Cytokines play a key role in the physiopathological mechanisms of asthma; the study of the structure, regulation and variations of the genes that encode for these molecules is therefore crucial. Cytokines have extremely diverse roles, and exert effects both as activators and inhibitors of the innate and adaptive immune response. Certain modifications in the expression or structure of these molecules, resulting from the presence of polymorphisms, may give rise to deregulation of the mentioned effects, and therefore to a predisposition to develop concrete asthma phenotypes.