Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idiopathic urticaria

• Autores: M. Tavakol, A.A. Amirzargar, Z. Aryan, A Z Bidoki, M. Gharagozlou, A. Aghamohammadi, M. Nabavi, Alireza Ahmadvand, N. Behniafard, Kazem Heidari
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 42, Nº. 6, 2014, págs. 533-538
• Idioma: inglés
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• Resumen

  • Background This study was performed to evaluate association of gene polymorphisms among proinflammatory cytokines and susceptibility to chronic idiopathic urticaria (CIU).

    Methods Ninety patients with prolonged urticaria more than 6 weeks were included as case group. Single nucleotide polymorphisms (SNPs) of IL-6 (G/C -174, G/A nt565) and TNF-? (G/A -308, G/A -238) were evaluated, using polymerase chain reaction (PCR); and the results were compared to the control group.

    Results G allele was significantly higher in the patients at locus of -238 of promoter of TNF-? gene (p < 0.001). Frequency of following genotypes were significantly lower in patients with CIU, compared to controls: AG at -308 and GA at -238 of TNF-? gene (p < 0.05 and p < 0.001, respectively), CG at -174 and GG at +565 of IL-6 gene (p < 0.05). Additionally, following genotypes were more common among patients with CIU: GG at -308 and -238 of TNF-? gene (p < 0.05 and p < 0.001, respectively), GG at -174 and GA at +565 of IL-6 gene (p < 0.05).

    Conclusions Pro-inflammatory cytokine gene polymorphisms can affect susceptibility to CIU. TNF-? promoter polymorphisms as well as IL-6 gene polymorphisms are associated with CIU.