Applicability of the Framingham 30-Year Risk Score Based on Body Mass Index. Usefulness in Cardiovascular Risk Stratification and Diagnosis of Carotid Atherosclerotic Plaque

• Masson, Walter ^[1] ; Siniawski, Daniel ; Krauss, Juan ; Cagide, Arturo
  1. [1] Hospital Italiano de Buenos Aires

     Hospital Italiano de Buenos Aires

     Argentina

     
• Localización: Revista Argentina de Cardiología, ISSN-e 0034-7000, Vol. 79, Nº. 6, 2011, págs. 514-520
• Idioma: inglés
• Títulos paralelos:
  • Función de Framingham a 30 años basada en el índice de masa corporal. Utilidad en la estratificación del riesgo cardiovascular y en el diagnóstico de placa aterosclerótica carotídea
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  • español

    Introducción La función o puntaje de Framingham tradicional a 10 años (PF10) subestima el riesgo cardiovascular en ciertas poblaciones. Extender el horizonte temporal a 30 años y evaluar la relación con la presencia de placas ateroscleróticas carotídeas (PAC) podría mejorar la estratificación del riesgo.Objetivos1) Determinar qué porcentaje de pacientes analizados con el PF10 se reclasifican con la aplicación del puntaje de Framingham a 30 años basado en el índice de masa corporal (PF30I). 2) Evaluar la concordancia entre los dos métodos de clasificación. 3) Analizar la prevalencia de PAC en una población estratificada por el PF30I. 4) Determinar la capacidad diagnóstica del PF30I para detectar PAC.Material y métodosSe realizó un eco-Doppler carotídeo y se calcularon el PF10 y el PF30I para eventos cardiovasculares“duros” en una población de pacientes en prevención primaria. Se determinó la prevalencia de PAC. Se realizó un análisis ROC y se evaluó la concordancia entre los dos métodos de clasificación.

  • English

    Background The traditional Framingham 10-year risk score (FS10) underestimates cardiovascular risk in certain populations. Extending its time-scale to 30 years and assessing its relationship with the presence of carotid atherosclerotic plaque (CAP) may improve risk stratification. Objectives1) To determine the percentage of patients previously classified with the FS10 who were reclassified when using Framingham 30-year risk score based on body mass index (FS30I); 2) to evaluate the consistency between both methods of classification; 3) to analyze the prevalence of CAP stratified by the FS30I; and 4) to determine the diagnostic potential of the FS30I to detect CAP.Material and MethodsA carotid Doppler ultrasound study was performed and the FS10 and FS30I for “hard” cardiovascular events were calculated in a population of primary prevention patients. The prevalence of CAP was determined. Receiver operating characteristic analysis and the consistency between both methods of classification were evaluated.ResultsA total of 410 subjects were included (age 48±11 years, 54% were men, 79% had low risk according to the FS10). The FS30I reclassified 64% of the total population and 66% of the low-risk subgroup. The prevalence of CAP was 28% and was gradually associated with the risk category. The area under the curve and optimal cutoff points of the FS30I to detect CAP were 0.862 and 21%, respectively. The consistency between FS10 and FS30I was low (kappa 0.15).ConclusionThe 30-year score reclassified a large number of patients and discriminated between those with or without evidence of carotid plaques.