Inflammatory mediators in patients with Dengue infection: role in early endothelial damage

• Vielma, Silvana ^[1]
  1. [1] Departamento de microbiología e inmunología, Universidad de Los Andes
• Localización: Avances en Biomedicina, ISSN-e 2244-7881, Nº. Extra 1 (Suplemento 1: V Jornadas Científicas del Instituto de Inmunología Clínica), 2013, págs. 48-48
• Idioma: español
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• Resumen

  • Several mechanisms have been proposed to explain the pathogenesis of dengue virus (DENV) infection. One of the most important finding is the production of pro-inflammatory cytokines as responsible of endothelial cells activation, plasma leakage and subsequently, disease severity. Methods: Our aim was to determined levels of inflammatory mediators (IL-8, TNF-α), soluble cell adhesion molecules (sICAM-1 and sVCAM-1) and soluble lymphocyte activation markers (sIL-2Rα, sTNF-RII/p75) during the course of DENV infection. Serum samples from fifty-two patients with confirmed DENV infection were collected during the acute (0-3 days after fever onset) and critical/recovery (4-7 days after onset) phases of the diseases. As controls, sera from non-febrile individuals were included. Patients were classified as dengue without warning signs (DwoWS), dengue with warning signs (DwWS) and severe dengue (SD).