Tratamiento domiciliario con meropenem

• Autores: N. Miserachs Aranda, Mercé Roca Massa, Laura Gratacós Santanach, Juan Pablo Horcajada Gallego, M. Sarasa-Nacenta
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 7, Nº. 4, 2005, págs. 257-265
• Idioma: español
• Títulos paralelos:
  • Home treatment with meropenem
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• Resumen

  • Objective: To determine whether aqueous solutions of 8-mg/mL and 16 mg/mL meropenem in an isotonic saline serum at room temperature and at 37 °C remain stable for at least 24 hours with the purpose of including patients in programs of antibiotic ambulatory treatment with pumps for continuous perfusion. Method: 12 samples of meropenem were prepared: 8 mg/mL and 16 mg/mL at room temperature and at 37 °C. The samples were analyzed with high performance liquid chromatography (HPLC). They were considered as stable if did not suffer a loss higher than 10%. Results: 24 hours after the preparation, the following remaining concentrations and t 90, respectively, were determined: 92.27% and 30.34 hours, 72.03% and 7.73 hours, for 8 mg/mL meropenem at room temperature and at 37 °C, respectively; 92.1% and 29.97 hours, 67.47% and 7.05 hours, for 16 mg/mL meropenem at room temperature and at 37 °C, respectively. Conclusions: The 8 mg/mL and 16 mg/mL meropenem solutions do not maintain their stability at body temperature (± 37 °C). This fact demonstrates the need for portable pumps for continuous perfusion with cold storage bags for a parenteral treatment at home