Estudio de pacientes con pancreatitis aguda. Análisis de la antibioterapia utilizada

• Autores: M. A. González Fernández, Jesús Llorente Gutiérrez, R. Fuentes, G. Casado, M. Moro
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 7, Nº. 5, 2005, págs. 351-361
• Idioma: español
• Títulos paralelos:
  • Study about patients with acute pancreatitis. Analysis of antibiotherapy used
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• Resumen

  • The aim of this study is to review several aspects like the origin of the pancreatitis, the diagnostic tests, prognosis, complications, and to analyze the use of antibiotherapy and also the indication for its use depending upon the characteristics of each episode. Method: The clinical records of patients that suffered episodes of acute pancreatitis (AP) during the second semester of 2002 have been reviewed, and to facilitate the data gathering, a data sheet was previously created for such a purpose. Afterwards, the data were entered in a database to support their analysis. Lastly, a pharmacotherapeutic algorithm has been created, according to the revised bibliography, with the purpose of analyzing which pharmacotherapeutic attitudes are adequate for it. Results: 88 episodes of acute pancreatitis (80 patients) have been reviewed, being the most frequent etiology the biliary lithiasis (60.2%). 78 episodes of mild acute pancreatitis and ten of severe acute pancreatitis (two exitus) were diagnosed. The most frequently used antibiotherapy was carbapenems (31%), piperacillin-tazobactam (26%), beta-lactamics (11%), and quinolones (10%). A total of 42.03% of the attitudes/standards related to the use of antibiotics was inadequate. Conclusion: Antibiotherapy was used in 44 episodes: 34 of those corresponded to light acute pancreatitis where, probably, the sole use of general support measures would have been sufficient. In the remaining 10 cases with grave acute pancreatitis the use of antibiotherapy would be definitely indicated