Polypharmacy related to increased risk of hip fracture in elderly patients

• Autores: O. García Molina, Raquel Olmos Jiménez, Francisco Javier Castellote Varona, Francisco Mendoza Otero, V. Arocas Casaño
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 16, Nº. 2, 2014, págs. 117-123
• Idioma: inglés
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• Resumen

  • Objective: Assess the association between polypharmacy and the use of drugs, and falls in elderly patients leading to hip fractures. Method: This is a population-based retrospective case-control study. The case group consists of patients aged =75 years old admitted to a tertiary hospital with hip fractures after accidental falls and the control group were randomized patients who were admitted to the Internal Medicine ward in the same period to obtain a relationship 1:1. The data were analyzed using SPPS v15.0. The data collection period was one year. Results: 61 patients were admitted with hip fractures obtaining a total of 122 patients. Mean age was 83.3 ±4.8 years (60.7% women) for the case group versus 81.97 ±4.04 (59% women) for the control group, p = 0.12. The number of drugs consumed was 7.2 ±3.3 in older patients with hip fractures respect 4.9 ±2.1 in patients without hip fractures, p <0.05. The most consumed drugs were proton-pump inhibitors (63.9%), followed by antihypertensive drugs (60.7%) and diuretics (55.7%). Statistically significant differences were found (p <0.05) in the consumption of benzodiazepines (OR 3.87, CI 1.77-8.46); antidepressants (OR 3.26, CI 1.18-9.02) and diuretics (OR 2.58, CI 1.24-5.39). Conclusions: The risk of hip fracture in elderly patients increases with the number of drugs taken and the use of benzodiazepines, antidepressants and diuretics