An Integrated Visualization and Basic Molecular Modeling Laboratory for First-Year Undergraduate Medicinal Chemistry

• Autores: Joseph M. Hayes
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 91, Nº 6, 2014, págs. 919-923
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target-drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid to the lecture material, 3D models of biological macromolecules exploiting Schrödinger software and the Maestro graphical user interface (GUI) is explored to enhance student learning. A considerably positive response was received from the participants. Background and details of the laboratory are outlined, while the student handout with answers is included as Supporting Information.