Relevancia clinica de la farmacocinetica de la carbamacepina

• Autores: Alberto Sánchez Romero, Rafael García Delgado, José Antonio Durán Quintana, José Antonio Abadín Delgado
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 2, Nº. 2, 2000, págs. 152-163
• Idioma: español
• Títulos paralelos:
  • The clinical relevance of the pharmacokinetics of carbamazepine
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• Resumen

  • Objective: To review the information that is available on the clinical pharmacokinetics of carbamazepine (CBZ). Methods: We carried out a bibliographical search of the literature in Medline (1974-1995), including controlled and non-controlled studies, case reports and reviews. We then proceeded to select the information from the article that the authors considered significant. Data synthesis: CBZ presents a variable and slow adsorption profile. It produces an active metabolite (carbamezapine-10-11- epoxide: CBZ-E) in lower concentration than the original drug. It stimulates its own biotransformation and that of other drugs. The relation between the dose and serum levels of CBZ in long term administration can be studied through correlation, the serum level/dose ratio or the metabolite/original drug ratio. This relation can be affected by such factors as the metabolite/original drug ratio. This relation can be affected by such factors as the degree of compliance to prescription, the interval between dosings, the dose and by the pharmacokinetic differences between patients (age, gestation, childbirth, liver disease and drug interactions).