GATA3: a master of many trades in immune regulation

• Autores: Yisong Y. Wan
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 6, 2014, págs. 233-242
• Idioma: inglés
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• Resumen

  • GATA3 has conventionally been regarded as a transcription factor that drives the differentiation of T helper (Th) 2 cells. Increasing evidence points to a function for GATA3 beyond controlling Th2 differentiation. GATA3 regulates T cell development, proliferation, and maintenance. Furthermore, recent studies have demonstrated important roles for GATA3 in innate lymphoid cells. Thus, GATA3 emerges as a factor with diverse functions in immune regulation, which are in some cases cell-type specific and in others shared by multiple cell types. Here, I discuss recent discoveries and the current understanding of the functions of GATA3 in immune regulation.